3Na Na Na Sarcolemma NCX ATP Na RyR

3Na Na Na Sarcolemma NCX ATP Na RyR

3Na Na Na Sarcolemma NCX ATP Na RyR Ca Ca 2K Na ATP 3Na PLB ATP ICa SR Ca T-Tubule Ca 2Na Ca by D.M. Bers NCX

3Na AP (Em) [Ca]i H Contraction Cyt Ca Na H 3Na Na Na Sarcolemma NCX ATP Na RyR Ca Ca 2K Na ATP 3Na

PLB ATP ICa SR Ca T-Tubule Ca 2Na Ca by D.M. Bers NCX 3Na AP (Em) [Ca]i H Contraction Cyt Ca Na H 3Na Na Na Sarcolemma NCX

ATP Na RyR Ca Ca 2K Na ATP 3Na PLB ATP ICa SR Ca T-Tubule Ca 2Na Ca by D.M. Bers NCX 3Na AP (Em) [Ca]i

H Contraction Cyt Ca Na H Ventricular Myocyte Ca SR ATP PLB ICa RyR Ca NaCaX ATP Ca Ca T-Tubule Cyt 2Na H H NaCaX

Na 3Na K Cl Ca Myofil by D.M. Bers ATP 3Na Ca Ca Ca 2K Na PLM Sarcolemma 3Na Ca Mito Crossbridge Cycle Chemical steps & Physical steps correlate http://www.sci.sdsu.edu/movies/actin_myosin.html Crossbridge Cycle Chemical steps & Physical steps correlate

http://www.sci.sdsu.edu/movies/actin_myosin.html Smooth Muscle EC-Coupling Pharmaco-electrical coupling or inhibited K channel Electro-mechanical coupling ICa driven APs or ICa can occur during tonic depol. at -50 to -15 mV Ca entry & Depol Ca channel Conductance 1.0 DAG-PKC Availability f Activation d 0.5 ICa "Window" Current 0.0 -60 -40 -20 0

Em (mV) and [Ca]i elevation via store-operated Ca channels Phasic IP3- & SR-dependent Pharmaco-mechanical Coupling Tonic Ca2+ influx-dependent (store operated Ca entry) 20 Smooth Muscle EC-Coupling Pharmaco-electrical coupling Electro-mechanical coupling Ca entry & Depol Many agents work via cGMP & cAMP cGMP stimulates MLC dephosporylation relaxation RyR cAMP stimulates SR Ca uptake, spontaneous local Ca release (Ca sparks) & Ca-activated K current hyperpolarization & relaxation IK(Ca) Pharmaco-mechanical Coupling

Recently Viewed Presentations

  • New Certifier Process - Santa Fe College

    New Certifier Process - Santa Fe College

    This is your Salary Certifier where keying will begin. This screen will list the Primary and Secondary Signature Authorities as well as you the Preparer. Time Calculator to assist in determining decimal value of hours/minutes. List of all employees on...
  • More Leads…

    More Leads…

    By: Roald Dahl . Until he was four years old, James Henry Trotter had had a happy life. He lived peacefully with his mother and father in a beautiful house beside the sea. There were always plenty of other children...
  • Climate Action Plan (CAP) Case Western Reserve University

    Climate Action Plan (CAP) Case Western Reserve University

    Renewable Energy/ Offsets RecommendationsPROPOSALS - Carbon Offsets. Biochar. Charcoal created by recycling waste biomass (such as animal manures and greenwaste) to produce renewable energy (displacing fossil fuels) and a stable form of carbon which can be sequestered long-term in soils.
  • 2011 ARGOS consortium meeting Australia Blake Orr ARPANSA

    2011 ARGOS consortium meeting Australia Blake Orr ARPANSA

    NPE10. Data from IDC: Seismic events that fall within Possible source region (PSR) The starting point of the assessment of NPE10 exercise was the Data Fusion Bulletins posted on the IDC web-site.
  • Acquiring Goods and Services - FEMA

    Acquiring Goods and Services - FEMA

    Acquiring Goods and Services Define the Requirement (PO) Prepare the Documentation (PO) Identify the Method (CO) Conduct Solicitation and Award (CO) Monitor the Contract (PO) Approve Payments (PO) Close Out (CO and PO) A NEED Creates . . . The...
  • 1915c Waiver Employment Billing Guidelines and ... - Texas

    1915c Waiver Employment Billing Guidelines and ... - Texas

    In Texas, individuals who receive SSI automatically qualify for Medicaid. The individual does not have to apply for Medicaid, just for SSI. ... Some individuals under age 18 can draw a monthly cash benefit from their parent's Retirement, Survivor or...
  • To everything thing there is a season A

    To everything thing there is a season A

    Ecclesiastes 08-10. Ecclesiastes 08-10. John 9:4 ~ I must work the works of Him who sent Me while it is day; the night is coming when no one can work. Ecclesiastes 08-10. Ecclesiastes 08-10. NLT ~ A poor, wise man...
  • Chapter 7 The Microscope 1 Physical properties of

    Chapter 7 The Microscope 1 Physical properties of

    When anisotropic crystals refract light, the resulting rays are polarized and travel at different velocities. ... its own refractive index value Determination of these refractive index data Provides information that helps to identify minerals present in a soil sample or...